242 Monitoring MDSC – a hurdle to immune checkpoints inhibitors
نویسندگان
چکیده
منابع مشابه
Immune checkpoints
1 This recognition was largely driven by the success of ipilim-umab, the monoclonal antibody that targets cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed on activated CD8 + T cells. CTLA-4 attenuates the immune response by countering the activity of CD28, a co-stimulatory receptor. 2 By targeting CTLA-4, ipilimumab effectively takes the " brakes " off T ce...
متن کاملTargeting immune checkpoints in malignant glioma
Malignant glioma is the most common and a highly aggressive cancer in the central nervous system (CNS). Cancer immunotherapy, strategies to boost the body's anti-cancer immune responses instead of directly targeting tumor cells, recently achieved great success in treating several human solid tumors. Although once considered "immune privileged" and devoid of normal immunological functions, CNS i...
متن کاملImmune checkpoints on innate lymphoid cells
In this issue of JEM, Taylor et al. (https ://doi .org /10 .1084 /jem .20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD...
متن کاملImmune checkpoints and immunotherapy for colorectal cancer
Colorectal cancer (CRC) remains one of the major causes of death worldwide, despite steady improvement in early detection and overall survival over the past decade. Current treatment paradigms, with chemotherapy and biologics, appear to have reached their maximum benefit. Immunotherapy, especially with checkpoint inhibitors, has shown considerable clinical benefit in various cancers, including ...
متن کاملTargeting Immune Cell Checkpoints during Sepsis
Immunosuppression is increasingly being recognized as one of the causes of increased morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction have been shown to cause an impaired ability to eradicate the primary infection and also lead to frequent occurrence of secondary opportunistic infections. Pre-clinical and clinical studies have shown that inhibitory immun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2020
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-sitc2020.0242